Cofftek cGMP шартында кальций 2-оксоглутарат жана альфа-кетоглутар кислотасын массалык түрдө өндүрүү жана жеткирүү мүмкүнчүлүгүнө ээ.

Альфа-кетоглутар кислотасы деген эмне (328-50-7)?

Альфа-кетоглутар кислотасы адамдын организминде табигый жол менен табылган биологиялык кошулма. Ошондой эле, диеталык кошумча түрүндө, альфа-кетоглутар кислотасы Кребс циклинде негизги ролду ойнойт (топтолгон энергияны бөлүп чыгаруу үчүн колдонулган бир катар химиялык реакциялар). Альфа-кетоглутар кислотасынын кошулмалары ден-соолукка пайдалуу жактарын, анын ичинде күчөтүлгөн спорттук көрсөткүчтөрдү жана зат алмашууну жакшыртат деп болжолдонууда.

Альфа-кетоглутар кислотасы (328-50-7) пайдасы

Жогоруда айтылгандай, бир нече алгачкы изилдөөлөр альфа-кетоглутар кислотасынын кошулуусунун пайдалуу жактары жөнүндө ишара кылды. Учурдагы айрым изилдөөлөр мындай дейт:
①Бөйрөктүн өнөкөт оорусу
Alpha-ketoglutaric acid has been used since the late-1990s to help break down and absorb protein in people on hemodialysis who require a low-protein diet. Recent evidence suggests that it may also delay the need for dialysis in people with advanced chronic kidney disease (CKD). According to a 2017 study in the journal PLoS One, researchers identified and followed 1,483 people with advanced CKD who used an alpha-ketoglutaric acid supplement called Ketosteril. The average duration of the follow-up was 1.57 years. Compared to a matched set of individuals who didn't take the supplement, those who did were less likely to require long-term dialysis. The benefits extended only to those who took more than 5.5 tablets per day, indicating the effects were dose-dependent. Despite the positive findings, it is unclear what role alpha-ketoglutaric acid played in comparison to the supplement's other active ingredients. Further research is needed.

②Ичеги-карындын ден-соолугу
Alpha-ketoglutaric acid supplements are believed to be anticatabolic, meaning that it slows or prevents or catabolism (the breakdown of tissues). By definition, a catabolic process is opposite to an anabolic process (in which tissues are built). A 2012 study in the Italian Journal of Animal Science reported that alpha-ketoglutaric acid prevented the breakdown of the intestines in lab rats fed a protein-free diet for 14 days. Rather than experiencing damage to the finger-like villi of the intestines—the expected outcome—the rats fed alpha-ketoglutaric acid had no visible damage compared to rats that weren't. Moreover, the rats provided the supplements were able to maintain normal growth despite the total lack of protein. Higher doses conferred to even better results. The findings appear to support alpha-ketoglutaric acid's anticatabolic effects. In addition to its application in chronic kidney disease, alpha-ketoglutaric acid may also aid people with intestinal toxemia and malabsorption disorders like celiac disease. Further research is needed.

③Атлетикалык Performance
By contrast, the anticatabolic effects of alpha-ketoglutaric acid appear to fall short when used for the purpose of muscle growth and athletic performance. According to a 2012 study in the Journal of the International Society of Sports Nutrition, alpha-ketoglutaric acid had no tangible effect on either muscle strength or exercise endurance in 16 men tasked with a resistance training workout. For this study, half of the men were given 3,000-milligrams (mg) of alpha-ketoglutaric acid, while the other half were given a placebo 45 minutes before doing bench press and leg press exercises. The following week, the supplements were flipped, with each half getting the alternate drug. Athletic performance was based on the total load volume (TLV) of the exercises performed in tandem with pre- and post-exercise heart rates. What these findings demonstrate is the absence of catabolic response is not the same thing as an anabolic response, especially among athletes.

Альфа-кетоглутар кислотасын (328-50-7) колдонот?

In heart surgery, alpha-ketoglutaric acid is sometimes delivered intravenously (into a vein) to reduce damage to the heart muscle due to the reduced blood flow. Doing so may also improve blood flow to the kidney following the surgery. Its use as a supplement is far less certain. Alternative practitioners believe that alpha-ketoglutaric acid can treat or prevent a wide variety of health conditions, including:
  • Катаракта
  • Өнөкөт бөйрөк оорусу
  • Гепатомегалия (боордун кеңейиши)
  • Ичеги токсемиясы
  • Оозеки тамак
  • остеопороз
  • Тендинопатия
  • Ачытма инфекциялар
Because of its role in releasing stored energy, alpha-ketoglutaric acid is often marketed as a sports performance supplement. Some proponents even assert that the supplement's antioxidant effects can slow aging. As is often the case with supplements that claim to treat multiple unrelated conditions, the evidence supporting these claims is weak. Some, like the supplement's "anti-aging" properties (based largely on a 2014 study involving nematode worms), border on the improbable.

Альфа-кетоглутар кислотасы (328-50-7) дозасы

Alpha-ketoglutaric acid supplements are available in tablet, capsule, and powder formulations and can be readily found online or in stores specializing in dietary supplements. There are no universal guidelines for the appropriate use of alpha-ketoglutaric acids. Supplements are typically sold in dosages ranging from 300 milligrams (mg) to 1,000 mg taken once daily with or without food. Doses of up to 3,000 mg have been used in studies with no adverse effects.

Альфа-кетоглутар кислотасы (328-50-7) мүмкүн болгон терс таасирлери

Alpha-ketoglutaric acid is considered safe and well-tolerated. Studies investigating the effects of alpha-ketoglutaric acid reported few adverse symptoms after three years of use. As a compound made from non-essential amino acids, alpha-ketoglutaric acid is not a substance on which you can readily overdose. Any excess in the body will either be excreted in urine or broken down into the basic amino acid building blocks for other purposes. With that said, the safety of alpha-ketoglutaric acid in pregnant women, nursing mothers, and children has not been established. This includes children with rare metabolism disorders such as alpha-ketoglutarate dehydrogenase deficiency (in which alpha-ketoglutaric acid levels are abnormally elevated).

Альфа-кетоглутар кислотасынын порошогу сатылат (Альфа-кетоглутар кислотасынын порошогун дүңүнөн кайдан сатып алса болот)

Our company enjoys long term relationships with our clients because we focus on customer service and providing great products. If you are interested in our product, we are flexible with the customization of orders to suit your specific need and our quick lead time on orders guarantees you’ll have great tasting our product on-time. We also focus on value-added services. We are available for service questions and information to support your business. We are an professional Alpha-Ketoglutaric Acid powder supplier for several years, we supply products with competitive price, and our product is of the highest quality and undergoes strict, independent testing to ensure that it is safe for consumption around the world.

Маалымат үчүн:

  1. Abrahams JP, Leslie AG, Lutter R, Walker JE. 2.8 структурасы, уйдун жүрөгү митохондриядан F1-ATPase резолюциясы. Nature. 1994; 370: 621-628. doi: 10.1038 / 370621a0.
  2. Alpers DH. Глутамин: адамдарда глутаминдин кошулуу себептерин маалыматтар колдойбу? Гастроэнтерология. 2006; 130: S106 – S116. doi: 10.1053 / j.gastro.2005.11.049.
  3. Ashkanazi J, Carpertier Y, Michelsen C. Булчуң жана жаракаттан кийинки плазма аминокислоталары. Ann Surg. 1980; 192: 78-85. doi: 10.1097 / 00000658-198007000-00014.